7/25/2023 0 Comments Skin barrier![]() The chapter on antimicrobial peptides discusses their role in detail. Antimicrobial peptides are produced in the deeper layers of the epidermis and are transported to the stratum corneum where they play a vital role in the first line of defence against potential pathogens. There are two possible scenarios: impairment of one barrier can lead to a deterioration of other barriers or it can be partly compensated by the upregulation of other barriers.īesides the stratum corneum lipids and the tight junctions, antimicrobial peptides expressed abundantly in the skin contribute immensely to barrier function. The one important thing which one learns from this chapter is that epidermal barrier defects found in several skin diseases due to genetic or environmental influences are in all likelihood not restricted to one barrier but are a consequence of the interaction between various barriers. If a molecule reaches the tight junctions from outside to inside in case the stratumcorneum barrier is impaired, it is likely to be stopped. These tight junctions are bidirectional which means these form a barrier to both sides. The localization of typical tight junction structures goes along with a barrier function of tight junctions in the granular layer. The effect of filaggrin and mutations in filaggrin gene on the stratum corneum lipid matrix is critically discussed. In the chapter on stratum corneum lipids, authors elaborate on how the composition of stratum corneum lipids is changed in lesional and non-lesional skin of patients with atopic dermatitis. The stratum corneum lipid barrier is affected in atopic dermatitis. ![]() The lipid matrix in the outermost layer of the skin is crucial for the skin barrier function: cholesterol, free fatty acids and ceramides are important components of this lipid matrix. Besides going into depth of the subject matter, the lucid reading makes understanding of a rather difficult and dry subject interesting. Other chapters in this section describe the importance of stratum corneum lipids, tight junctions, antimicrobial peptides and biological variation in skin barrier function. The first chapter in section I discusses in detail the role of filaggrin in skin barrier function. The final section highlights the clinical aspects of the skin barrier function. Section I deals with basic parameters involved in skin barrier function, section II describes the external factors influencing skin barrier while the third section discusses the treatments improving the skin barrier. Internally, the skin helps to maintain homeostasis and protects from enhanced loss of water from the body. Physically, it protects from external threats such as infectious agents, chemicals, systemic toxicity and allergens. The skin barrier is important to human life. The importance of skin barrier cannot be overemphasized. Researchers in the field, dermatologists, occupational physicians, and related industry will find this publication an essential source of information.This book is the 49 th volume in the ongoing series, “Current Problems in Dermatology”. Further sections are dedicated to clinical implications of skin barrier integrity, factors influencing the penetration of the skin, influence of wet work, and guidance for prevention and saving the barrier.ĭistinguished researchers have contributed to this book, providing a comprehensive and thorough overview of the skin barrier function. ![]() Biological variation and aspects of skin barrier function restoration are discussed as well. It covers new basic research on skin markers, including results on filaggrin and on methods for the assessment of the barrier function. This book is an interdisciplinary update offering a wide range of information on the subject. ![]() ![]() Since the role of barrier integrity in atopic dermatitis and the relationship to filaggrin mutations was discovered a decade ago, research focus has been on the skin barrier, and numerous new publications have become available. Inward/out it is responsible for body integrity and outward/in for keeping microbes, chemicals, and allergens from penetrating the skin. Although a very fragile structure, the skin barrier is probably one of the most important organs of the body. ![]()
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